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All types of adrenal hyperplasia were reviewed exhaustively by Bongiovanni and Root See precocious puberty for a simulating condition. Some had suggested the existence of 2 different hydroxylating systems, one specific for progesterone and concerned with aldosterone synthesis and the other specific for alpha-hydroxyprogesterone involved in cortisol synthesis. However, Orta-Flores et al. The authors suggested that both sites are defective in the salt-losing variety and only the second in the non-salt-losing form.
Presentation with gynecomastia and bilateral testicular masses was reported by Kadair et al. Others have reported bilateral testicular tumors. However, McGuire and Omenn presented data indicating that patients with congenital adrenal hyperplasia do not have higher IQs than expected from the family background. Two sibs were normal.